Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIA

Exclusion Criteria

• •1. Other than NSAIDs or intra-articular injections, participant has been treated for JIA with lack of efficacy with:
• •1. More than 2 different classes of therapies, or
• •2. More than 3 medications in total
• •2. Participant has received high-dose steroids (\>=0.2 mg/kg/day) within the 28 days prior to screening.
• •3. Participant has had active systemic disease (fever, systemic rash) within the 3 months prior to screening including any of the following lab manifestations at screening:
• •1. Ferritin \>1000 ng/mL
• •2. White blood cell (WBC) ≥15,000/mm\^3
• •4. Participant has had an active acute systemic infection within 2 weeks of screening. involving fever (100.4⁰F or higher) for more than 24 hours, requirement for systemic antibiotics or antivirals, GI symptoms lasting 48 hours or more, or the need to hold second line medications for JIA (methotrexate or biologic).
• •5. Participant has a history of arrhythmia.
• •6. Participant has been diagnosed with postural orthostatic tachycardia syndrome (POTS).
• •7. Participant has received an intra-articular cortisone injection within the 28 days prior to screening.
• •8. Participant has received treatment with an investigational drug or device during the 28 days prior to screening or within five half-lives of the investigational drug prior to screening/baseline, whichever is the greater length of time.
• •9. Participant has received chronic treatment with an anti-cholinergic medication, including over the counter medications.
• •10. Participant has received treatment with rituximab:
• •1. Within one year of screening
• •2. At any time previously without documented B cell repletion
• •11. Participant has a comorbid disease that has required treatment with corticosteroids within the past year.
• •12. Participant has an implantable electronic device such as a pacemaker, defibrillator, hearing aid, cochlear implant, insulin pump or deep brain stimulator.
• •13. Participant has used cutaneous vagus nerve stimulation within 12 weeks prior to screening.
• •14. Participant has received a live attenuated viral vaccine within 28 days prior to screening or is expected to receive one during the study.
• •15. Participant has any condition which, in the opinion of the investigator, would jeopardize the participant's safety following exposure to a study intervention.
• •16. Participant has any past or current medical problems or findings from a physical examination or laboratory testing that are not listed above but which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements, or may impact the quality or interpretation of the data obtained from the study.