The Natural History Study of Patients With Sanfilippo Disease(s) (MPS3)

Exclusion Criteria

• •1. Unwilling or unable to follow protocol requirements as per principal investigator
• •2. Any serious or chronic medical illness, including significant cardiac or severe debilitating pulmonary disease as determined by the investigator.
• •3. Any medical condition that, in the opinion of the PI, would place a subject at undue risk
• •4. Inability to cooperate for clinical and safety data collection
• •5. Use of genistein or Miglustat within one week of the study
• •6. Evidence of hepatitis B or hepatitis C infection upon serological testing at screening
• •7. Currently participating in another interventional drug trial or has completed an interventional trial less than one month prior to the screening visit