Opium Tincture Against Chronic Diarrhea - Healthy

Exclusion Criteria

• •Known allergy towards pharmaceutical compounds similar to Dropizol.
• •Participation in other studies within 14 days of first visit (1 year if opioids involved).
• •Expected need of medical/surgical treatment during the study
• •History of psychiatric illness (e.g. mental retardation, schizophrenia, affective disorders (depression), personality disorders or treatment with psychoactive medications)
• •History of substance abuse (e.g. alcohol, nicotine, tetrahydrocannabinol (THC), benzodiazepine, central stimulants and/or opioids)
• •Family history of substance abuse
• •Known increased intracranial pressure
• •Known major stenosis of the intestines
• •Planned MRI within the next 3 months
• •Metal implants or pacemaker
• •Known severe decreased renal function (defined as estimated glomerular filtration rate (eGFR) below 45)
• •Known severe decreased hepatic function (defined as Child-Pugh class B or higher)
• •Treatment with Monoamine oxidase (MAO) inhibitors during the entity of the study
• •Known severe chronic obstructive pulmonary disease (COPD) or acute severe asthma (defined as forced expiratory volume in 1 second (FEV1) below 50 % or acute ongoing exacerbation)
• •Known cor pulmonale
• •Female participants that are lactating
• •Medicine known to affect gastrointestinal motility must not be initiated during the entity of the study
• •Use of any analgesic medication within 48 hours before start as well as for the duration of the study (urine drug test will be performed prior to treatment start).
• •Intake of alcohol within 48 hours before start of study period as well as for the duration of the study.