A Trial of HRS8179 on Brain Swelling After Large Hemispheric Infarction

Inclusion Criteria

• •1. Fully understand and voluntarily participate in this research, and sign the informed consent form (the informed consent form can be signed voluntarily by the person or legal representative);
• •2. Aged 18\~80, regardless of gender;
• •3. A clinical diagnosis of acute ischemic stroke in the middle cerebral artery (MCA) territory;
• •4. NIHSS ≥ 10 points at screening;
• •5. A large hemispheric infarction is defined as: lesion volume of 80 to 300 cm3 on magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI), or computed tomography perfusion (CTP).
• •6. The study drug initiated must be no later than 10 hours when stroke onset;