Total Bilirubin ≤ 1.5x institutional upper limit of normal (ULN) AST(SGOT)/ALT(SGPT) ≤ 3 × institutional ULN
Renal:
Estimated creatinine clearance (CrCl)≥ 50 mL/min by Cockcroft-Gault formula
You may not be if
Stage IV cancer
CTCAE neurological function \> grade 1 at baseline
Mental limitation that precludes understanding of or completion of questionnaires
History of diabetes or other neurological disorders
Preexisting peripheral neuropathy
Prior exposure to neurotoxic chemotherapy
Currently taking medication to treat or prevent neuropathy
Have non-MRI compatible metallic objects on/in body
Have metallic hardware in the lower extremity which is MR compatible however would create too much artifact for MR examination
Pregnant or lactating patients. Women of childbearing potential and sexually active men must use an effective contraception method during rreatment and for three months after completing treatment. Patients of childbearing potential must have a negative serum or urine B-hCG pregnancy test at screening.
History or current evidence of central serous retinopathy (CSR) or retinal vein occlusion (RVO) or current risk factors for RVO (e.g. uncontrolled glaucoma or ocular hypertension, history of hyperviscosity) or macular degeneration.
QTc prolongation defined as a QTcF \> 500 ms
Known glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.
Clareo Health | Evaluation of Hydroxychloroquine to Prevent CIPN
