Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer

Exclusion Criteria

• •Distant metastasis from pancreas cancer.
• •Contraindication to having a magnetic resonance imaging (MRI) scan.
• •Prior abdominal radiation therapy.
• •History of any primary malignancy with the exception of:
• •1. Malignancy treated with curative intent and with no known active disease for at least 3 years before enrollment on this study.
• •2. Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease.
• •3. Adequately treated carcinoma in situ without evidence of disease (i.e., cervical carcinoma in situ; superficial bladder cancer).
• •Any unresolved toxicity (Common Terminology Criteria for Adverse Events version 5.0 \> grade 2) from previous anti-cancer therapy. Participants with irreversible toxicity that is not reasonably expected to worsen by treatment on this study are permitted to enroll on this study.
• •History of inflammatory bowel disease (i.e., Crohn's disease, ulcerative colitis).
• •Any condition in the opinion of the investigator that would interfere with evaluation of study treatment or interpretation of patient safety or study results.
• •Participants who are pregnant or breastfeeding. Patients with an electrical implantable device in the torso. Examples of electrical implanted medical devices include spinal cord stimulators, vagus nerve stimulators, pacemakers, and defibrillators.
• •History of significant uncontrolled cardiovascular disease. Significant cardiac disease includes second/third degree heart block; significant ischemic heart disease; poorly controlled hypertension; congestive heart failure of the New York Heart Association (NYHA) Class II or worse.
• •History of arrhythmia that is symptomatic or requires treatment. Patients with atrial fibrillation or flutter controlled by medication are not excluded from participation in the trial.
• •Known allergy to medical adhesives or conductive hydrogel \[gel used on electrocardiogram (ECG) stickers or transcutaneous electrical nerve stimulation (TENS) electrodes\].