Acupuncture in Chemotherapy-induced Peripheral Neuropathy in Women With Breast Cancer

Exclusion Criteria

• •Patients with diagnosis of metastatic breast cancer
• •Pre-existing peripheral neuropathy in the 28-day period before the start of chemotherapy
• •Any pre-existing condition which can both lead to or be a concomitant factor for neuropathy onset, such as not controlled diabetes mellitus, paralysis, multiple sclerosis, AIDS and Herpes Zoster
• •Patients with amputation and/or severe peripheral vascular disease (peripheral revascularization interventions needed, AOCP\> stage II, rheumatologic disorders affecting arteriole or microcirculation)
• •Patient with history of spinal cord surgery
• •Patient with history of chronic alcoholism
• •Concomitant use of pharmacological agents which can cause neuropathic pain as an adverse event, except for chemotherapy
• •Patient who already experienced acupuncture for any condition
• •Patient currently in treatment with duloxetine, gabapentin, pregabalin or other drugs for the treatment of neuropathic pain
• •Patient with history of psychiatric disorders before breast cancer diagnosis (major depressive disorders, bipolar disorder, suicidal tendency)