Galleri® in the Medicare Population.

Exclusion Criteria

• •For Galleri + UC (Galleri-Tested Arm):
• •Evidence of having had a previous MCED test (including but not limited to the Galleri test, e.g. CancerSeek, PanSeer). Participation in a study such as GRAIL's STRIVE study where results were not returned is not an exclusion criterion.
• •Undergoing clinical evaluation for suspicion of cancer within 6 months prior to enrollment. Personal history of hematologic malignancy and/or invasive solid tumor (excluding non-metastatic basal cell carcinoma and squamous cell carcinoma of the skin):
• •1. Diagnosed ≤3 years before expected enrollment date and/or
• •2. Diagnosed \>3 years before expected enrollment date and never treated and/or
• •3. Currently undergoing active cancer management (not including adjuvant hormone therapy for breast or prostate cancer).
• •Current pregnancy.
• •Individuals who are currently inpatients at a participating site.
• •Individuals who are not willing or able to comply with the protocol procedures.
• •Individuals who are not currently registered patients at a participating center.
• •Previous or current employees or contractors of GRAIL.
• •For UC (Not Galleri-tested Arm):
• •Evidence of having had a previous MCED test (including but not limited to the Galleri test, eg.CancerSeek, PanSeer). Participation in a study such as GRAIL's STRIVE study where results were not returned is not an exclusion criterion.
• •Undergoing clinical evaluation for suspicion of cancer.
• •Personal history of hematologic malignancy and/or invasive solid tumor (not including non-metastatic basal cell carcinoma and squamous cell carcinoma of the skin):
• •1. Diagnosed ≤3 years before expected enrollment date and/or
• •2. Diagnosed \>3 years before expected enrollment date and never treated and/or
• •3. Currently undergoing active cancer management (not including adjuvant hormone therapy for breast or prostate cancer).
• •Current pregnancy.
• •Individuals who are currently inpatients at a participating site.