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CEREBELLAR INVOLVEMENT IN MOTOR, COGNITIVE AND EMOTIONAL PROCESSES IN MYOCLONUS DYSTONIA
Background: Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype. The mechanisms underlying these non-motor symptoms are still poorly understood. Objective: To investigate the neural correlates of cognition and emotion in DYT-SGCE. Design: Participants will have 1 - 2 visits at the clinical center. The total participation time is less than 24 hours. Participants will have a medical interview and a neurological exam. They may give a urine sample before MRI. Participants will have a short neuropsychologic and psychiatric interviews. Participants will have MRI scans. They will do small tasks or be asked to imagine things during the scanning.
Eligibility: DYT-SGCE patients and healthy volunteers (HV) between 15 and 60 years old.
Age
15 - 60 years
Sex
ALL
Healthy Volunteers
Yes
Brain Institute
Paris, Paris, France
Start Date
January 20, 2023
Primary Completion Date
February 19, 2024
Completion Date
February 19, 2024
Last Updated
January 23, 2026
47
ACTUAL participants
Lead Sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Collaborators
Data Source & Attribution
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