Efficacy and Safety of Ultra_HYPofractionated RadiotHerapy in Women With BrEast CaNcer Receiving Regional Nodal Radiation vs Nodal Moderate Hypofractionated Radiotherapy

Inclusion Criteria

• •Information to the patient and signed informed consent;
• •Women aged ≥18 years;
• •Breast conserving surgery;
• •Invasive adenocarcinoma (except classic invasive lobular carcinoma);
• •TNM (Tumor, Nodes, Metastasis) pathologic stage pT1-3 and pN1-3a M0, with indication of lymphatic drainage according to institutional protocol;
• •Eastern Cooperative Oncology Group (ECOG) 0 -1;
• •Minimum microscopic margin of non-cancerous tissue of 2 mm (excluding deep margin if in the deep fascia);
• •No previous breast or mediastinal radiotherapy;
• •No hematogenous metastases;
• •Ability to carry out long-term follow-up;