Precise Stratification of Genetic Risk of Ovarian Function Impairment

Exclusion Criteria

• •1. Chromosome karyotype abnormality;
• •2. Iatrogenic ovarian injury: history of radiotherapy, chemotherapy (reproductive toxic drugs such as alkylating agents) and ovarian surgery;
• •3. Ovarian mass: there is abnormal echo in the ovary under ultrasound, and the maximum diameter is greater than 4cm.
• •4. Pregnant and lactating women;
• •5. Polycystic ovary syndrome, hyperprolactinemia, hyperandrogenemia, hypothyroidism, adrenal dysfunction and other endocrine diseases affect ovulation;
• •6. Patients with cardiovascular, liver, kidney, hematopoietic system and other serious primary diseases and psychosis;
• •7. Patients who are participating in other clinical trials or have participated in other clinical trials in the past month;
• •8. Other patients determined by the investigator to be unsuitable for participation in this study.