Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Centre Hospitalier Universitaire de Nīmes
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
The patient must have given their free and informed consent and signed the consent form
The patient must be a member or beneficiary of a health insurance plan
Women of childbearing potential must have effective contraception during the study period. Effective contraception is defined by a low failure rate (less than 1% per year) when used correctly and consistently, such as implants, injectables, oral contraceptives, IUDs, abstinence, or partner vasectomy. A urine pregnancy test will be performed at inclusion.
You may not be if
The subject is participating in another therapeutic study, or is in a period of exclusion determined by a previous study
The subject is unable to express their consent
It is impossible to give the subject informed information
The patient is under safeguard of justice or state guardianship
Pregnant or breastfeeding
Infectious disease or vaccination within previous 3 months
Chronic psychiatric disease, or disease that, in the opinion of the investigator ,may put the patient at risk or affect compliance.
Chronic inflammatory or dysimmune disease or subject on immunomodulatory or immunosuppressive therapy (including corticosteroids) within the last 3 months.
Uncontrolled epilepsy.
Known vitamin D deficiency secondary to active or other digestive disease (celiac disease, IBD, gastrectomy or bypass, cirrhosis, short bowel syndrome, nephrotic syndrome, hyperthyroidism, hypoparathyroidism, cancer, granulomatous pathology, lymphoma, rickettsiosis).
History of hypercalcemia, osteopenia or osteoporosis, urinary lithiasis, heart rhythm disorders.
Pathology requiring a daily intake of more than 1 gram of Calcium.
Contraindication to vitamin D3 treatment as mentioned on the VIDAL documentation of UVEDOSE.
Treatment affecting vitamin D metabolism other than corticosteroids: anti-epileptic drugs \[phenobarbital, primidone, phenytoin\], rifampicin, isoniazid, ketoconazole, 5-FU and leucovorin, thiazide diuretic.
Active vitamin supplementation or dietary supplements rich in vitamin D.
Present or past neurological symptoms that may suggest an undiagnosed inflammatory neurological pathology.
Clareo Health | Peripheral Immunological Effects of High-dose Vitamin D Treatment in Healthy Subjects
