PBMC as Biomarkers of Diabetic Cardiomyopathy

Inclusion Criteria

• •Patient attending a scheduled cardiology or endocrinology follow-up visit
• •Patient fasting for blood sampling
• •Male or female aged 40 to 85 years inclusive
• •Patient not opposing participation in this research
• •Patient agreeing to the storage of biological samples and to genetic analyses
• •Group 1: No-T2D +MS / No-HF (control group)
• •\- Patient without T2D or MS and without heart failure coming to a consultation or day hospital for another reason (e.g. screening for atypical symptom, etc.)
• •Group 2: No-T2D +MS / HFpEF or HFmrEF
• •Patient without T2D or MS
• •HFpEF or HFmrEF. diagnosed
• •Group 3: T2D+MS / no-HF
• •Patient diagnosed with T2D+MS
• •\- Absence of HF
• •Group 4: T2D +MS / HFpEF or HFmrEF
• •Patient diagnosed with T2D and MS
• •HFpEF or HFmrEF. diagnosed
• •History of cardiovascular disease (valvular disease \[greater than moderate severity\], radiation-induced, post-cardiotoxic chemotherapy, amyloidosis, etc.) other than HFpEF or HFmrEF
• •Acute or ongoing systemic inflammatory or infectious disease
• •History of known coronary artery disease
• •Uncontrolled hypertension (\>160/100 mmHg)
• •Pregnant or breastfeeding women (based on interview)
• •Persons deprived of liberty by judicial or administrative decision
• •Persons undergoing psychiatric care
• •Patient under legal protection (guardianship or curatorship)
• •Subject participating in another interventional study with an ongoing exclusion period
• •Chronic kidney disease (eGFR \<30 mL/min/1.73 m²)
• •Group 1: No-T2D +MS / No-HF (control group)
• •Presence of diabetes (whatever the type) and MS
• •Presence of heart failure or other known heart disease
• •Group 2: No-T2D +MS / HFpEF or HFmrEF
• •Presence of diabetes (whatever the type) and MS
• •Left Ventricular Ejection Fraction (LVEF) on ultrasound ≤ 40%
• •Group 3: T2D+MS / no-HF
• •Without diabetes or other type of diabetes than T2D
• •Presence of Heart failure (all types)
• •Group 4: T2D +MS / HFpEF or HFmrEF
• •Absence of diabetes or presence of another type of diabetes than T2D
• •LVEF on ultrasound ≤ 40%