The Clinical Features and Pregnancy Outcomes of RA Patients

Exclusion Criteria

• •Women who meet any of the following criteria will be excluded from the study
• •1. Any known etiology of previous pregnancy loss
• •1. Known paternal, maternal or embryonic chromosomal abnormalities.
• •2. Maternal endocrine dysfunction: luteal insufficiency; polycystic ovary syndrome; premature ovarian failure (follicular phase stimulating hormone, FSH ≥ 20uU/L).
• •3. Hyperprolactinemia; diabetes mellitus; other abnormalities of the hypothalamic pituitary-adrenal axis.
• •4. Maternal anatomical abnormalities: uterine malformations; Asherman syndrome; cervical insufficiency; uterine fibrosis greater than 5 cm. vaginal infection.
• •5. Any known serious cardiac, hepatic, renal, hematologic or endocrine disease.
• •2. Any active infection, including bacterial, alisla virus (VZV), human immunodeficiency virus (HIV), human papillomavirus (HPV), syphilis, tuberculosis, fungal infections, etc.
• •3. Hypersensitivity to prednisone, hydroxychloroquine, low molecular weight heparin or aspirin
• •4. History of the following diseases.
• •1. Past history of peptic ulcer or upper gastrointestinal bleeding.
• •2. Past history of malignancy.
• •3. Past history of epilepsy or mental disorder.
• •4. Female has been diagnosed with SLE
• •5. Women who do not consent or are unable to complete pregnancy and postpartum follow-up.