Biopsy Versus Resection in Elderly Glioblastoma Patients. A Prospective Cohort Study.

Exclusion Criteria

• •1. Tumors of the cerebellum, brain stem or midline
• •2. Multifocal contrast enhancing lesions
• •3. Substantial non-contrast enhancing tumor areas suggesting low grade gliomas with malignant transformation
• •4. Medical reasons precluding MRI (e.g. pacemaker)
• •5. Inability to give consent as assessed by neurosurgeon (e.g. language barrier)
• •6. Severe aphasia prohibiting neurolinguistic testing and comprehension of informed consent
• •7. Previous brain tumor surgery
• •8. Previous low-grade glioma
• •9. Second primary malignancy within the past 5 years with the exception of adequately treated in situ carcinoma of any organ or basal cell carcinoma of the skin.