Glecaprevir/Pibrentasvir for Post-traumatic Stress Disorder

You may be eligible if

• 1. Age 19-70 years
• 2. Weight ≥ 45 kg
• 3. Diagnosed with PTSD as determined by the CAPS-5 within seven days of enrollment
• 4. Eligible for Veterans Affairs healthcare
• 5. If person with childbearing potential, use of acceptable method of birth control (i.e., effective contraceptives, abstinence) is required.
• 6. Able to read, understand, and sign the informed consent document.
• Exclusion (unable to participate) Criteria:
• 1. Pregnant or lactating person
• 2. Moderate or severe hepatic impairment (Child-Pugh B or C)
• 3. History of prior hepatic decompensation
• 4. Current use of drugs listed as having significant drug interactions on prescribing label
• 5. Advanced liver disease
• 6. Current or prior hepatitis B infection
• 7. Prior clinical use of GLE/PIB or HCV NS5A inhibitor AND NS3/4A protease inhibitor
• 8. Current HCV infection
• 9. Current psychosis or mania
• 10. Significant suicidal ideation
• 11. Unstable medical conditions
• 12. Current severe alcohol or substance use disorder (excluding nicotine)
• 13. Evidence-based PTSD psychotherapy changes in the past two months
• 14. Evidence-based PTSD medication changes in the past two months