MS patient already included in previous studies using MRI and/or PET-MR (INFLASEP (NCT02305264), FLUMATEP (NCT01651520) or SHADOWTEP) will be proposed a long-term follow up study.
Participants will undergo :
* a full neurological examination including EDSS
* medical history and comorbidities (including smoking)
* concomitant and MS treatments
* neuropsychological testing
* Blood sample for serum biobanking
* multimodal MRI
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Multiple Sclerosis Patient already enrolled in one of those 3 protocols since 8 years or more: INFLASEP, FLUMATEP 1-2 or SHADOWTEP
Adult patient
Affiliation to a social security scheme or beneficiary of such a scheme (Except "Aide Médicale d'Etat")
Consent obtained
You may not be if
Any reasons, which does not allow to perform MRI, including claustrophobia, the implant of a pace maker or the presence of an intra-ocular foreign body (a contra- indication questionnaire will be filled in beforehand)
Pregnancy, breast-feeding, lack of efficient contraception
Current symptoms of severe or uncontrolled renal, hepatic, hematological, gastrointestinal, pulmonary or cardiac disease, or any other chronic neurological diseases
Unwillingness to be informed in case of abnormal MRI (with a significant medical anomaly)
Enrolment in another interventional study protocol for the duration of his or her participation without physician's agreement
Patient under legal protection
Clareo Health | Multimodal Imaging Signatures of the Biological Mechanisms Underlying Neurodegeneration in Multiple Sclerosis
