A Study of Step-up in Bronchial Asthma as a New End Point in Asthma Control (SURFE)

Exclusion Criteria

• •1. Severe asthma exacerbation in last 3 months.
• •2. Use of any systemic corticosteroids in last 12 weeks.
• •3. Use of depot systemic steroids in last 12 weeks.
• •4. Any concurrent respiratory disease as bronchiectasis, COPD, lung fibrosis, …
• •5. Current or known history of tuberculosis in any organ.
• •6. Current malignancy or any history of malignant disease for the past 5 years.
• •7. Subjects receiving any medications with known drug interaction with study medications.
• •8. Use of beta-blockers including eye drops.
• •9. Any significant concurrent disease as cardiac, hepatic, renal, …
• •10. Current or history of alcohol or drug abuse.
• •11. Current or history of significant psychiatric disease.
• •12. Current or history of significant immunodefieciency.
• •13. History of receiving any biological therapy for asthma for the last 3 years or currently eligible for any biological therapy for asthma.
• •14. Subjects under any immuno-modulating therapy including biological therapy for any other indication. Subjects may be allowed to participate after 5 times half-live of the concerned drug.
• •15. Any known allergy or contraindication to any of the study medications.