The research study procedures include screening for eligibility and the collection of data and biospecimens. Non-operative management is offered as part of routine clinical care.
It is expected that up to 60 participants will be enrolled, with the goal that 55 participants will take part in this research study .
Participants enrolled on the study will remain on study for up to 60 months.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Participants with T3, T4, or node-positive non-metastatic rectal cancer.
Participants must have original tumor tissue (formalin-fixed, paraffin embedded specimens) available for analysis or be willing to undergo a baseline research biopsy.
Participants must be 18 years of age or older.
ECOG 0-2.
Participants must be eligible for at least 3 months of FOLFOX, FOLFIRINOX/FOLFOXIRI, or CAPOX
Participants must be eligible for long course chemoradiation to 40-54 Gy.
Participants must be able to understand and willing to sign a written informed consent document.
You may not be if
Participants must not have any other organ cancer evident at the time of enrollment.
Participants may not have any other concurrent serious illness that makes participation on this study impractical or clinically inappropriate.
Participants must not be actively or planning to be pregnant or breastfeeding
