Evaluation of the Antibacterial Effect of a Toothpaste Containing Zinc Lactate

Exclusion Criteria

• •1. Participation in any other clinical study or test panel including clinical studies with oral hygiene formulations within the one month prior to entry into the study.
• •2. History of dental prophylaxis or treatments in the past month or during study duration.
• •3. History of medical treatments (e.g: antibiotic, anti-inflammatory, anticoagulant, etc.) during the month preceding study enrollment.
• •4. Subjects scheduled for any medical procedure during the course of the study.
• •5. Difficulty complying with study procedures and examinations such as excessive gagging during oral assessment etc.
• •6. History of significant adverse effects following use of oral hygiene products such as toothpastes and mouthrinses. Allergies to personal care/consumer products or their ingredients.
• •7. History of diabetes, hepatic, renal disease, inflammatory conditions or transmittable diseases, e.g. heart disease or AIDS.
• •8. History of rheumatic fever or medical conditions that require prophylactic antibiotics coverage prior to dental procedures.
• •9. Presence of oral lesions.
• •10. History of active or severe periodontal disease (PD \> 4) and loose teeth.
• •11. Gross dental caries, severe generalized cervical abrasion and/or enamel abrasion, large fractured or temporary restorations (based on visual examinations).
• •12. Fixed or removable orthodontic appliances or removable partial dentures.
• •13. Current smokers and subjects with a history of alcohol or drug abuse.
• •14. Use of phenolic flavored products, such as mint flavored candies and chewing gum, during the study period.
• •15. Unable to refrain from oral hygiene for twelve (12) hours prior to scheduled visits.
• •16. Positive Coronavirus Disease 2019 test 48 hours prior to the screening visit.