History of bariatric surgery or active participation in weight-loss program

Major medical or neurological disorder (e.g., diabetes, multiple sclerosis)

Anemia or impaired kidney or liver function

Known gallbladder disease or gallstones

Hypertriglyceridemia (\>350 mg/dl)

Current use of orlistat or other weight-loss medications or other medications known to alter appetite (e.g., atypical anti-psychotics)

More than moderate level of physical activity (\>1000 met-min/wk)

Pregnancy, menopause, or breastfeeding

MRI contraindication (e.g., implanted metal, claustrophobia)

Lifetime eating disorder

Current smoking or heavy alcohol use (≥ 2 drinks per day for females and ≥ 3 drinks per day for males)

Weight \> 350 pounds (MRI limit)

Dietary restrictions (e.g., vegan) incompatible with controlled diets

Does What You Eat Affect Your Brain