ReACHallenge Trial: Acetylcholine Rechallenge After Pretreatment With Vasoactive Drugs

Exclusion Criteria

• •Obstructive coronary artery disease (both chronic and acute coronary coronary syndromes)
• •Any cardiomyopathy (including takotsubo stress cardiomyopathy) or severe valvular disease
• •LVEF \< 50%
• •Long QT syndrome (LQTS) - genetic or acquired
• •Ventricular paced rhythm
• •Renal failure with eGFR \< 40 ml/min
• •Thyroid stimulating hormone (TSH) \< lower limit of normal (LLN). A subject taking thyroid replacement therapy may be enrolled with TSH level below LLN if, in the opinion of the investigator, the subject is in a clinically euthyroid state.
• •Known hypersensitivity or contra-indication for either acetylcholine, verapamil, nicorandil or nitroglycerine.
• •Pregnant female subjects. Female subjects of child-bearing potential should be on adequate contraceptive measures or are to be screened with a urine pregnancy test.