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Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA) | Clinical Trials | Clareo Health

COMPLETEDPHASE2

Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA)

NCT05615922•NYU Langone Health

View on ClinicalTrials.gov

Summary

The purpose of this study is to establish the feasibility of a program of remotely supervised transcranial direct current stimulation (RS-tDCS) paired with language skills practice for people living with the semantic or logopenic variants of primary progressive aphasia (PPA). There are currently no established standard-of-care treatments for PPA. This study will evaluate whether RS-tDCS combined with language skills practice is a feasible study design for individuals with PPA.

Eligibility

Age

45 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Primary progressive aphasia diagnosis (logopenic or semantic variant)
•2. Peabody Picture Vocabulary Test (PPVT) score \< -1.0 SD, serving as a literacy proxy for premorbid cognitive ability and ensuring English language fluency sufficient for participation in the study procedures.
•3. WAIS-IV Matrix Reasoning T score \< 20, serving as an index of current general cognitive functioning to exclude those with severe cognitive impairment
•4. Stable and continuous access to internet service, email (WiFi "hotspot" to be provided if needed)
•5. Fluent in English language (due to outcomes validated in English versions only)

Exclusion Criteria

•1. Disorder other than PPA known to cause language dysfunction
•2. Diagnosis of nonfluent/agrammatic subtype of primary progressive aphasia
•3. History of traumatic brain injury
•4. Uncontrolled seizure disorder and/or recent (\<5 years) history of seizure
•5. Metal implants in the head or neck
•6. Any skin disorder or skin sensitive area near stimulation locations
•7. Pregnant or breastfeeding

Locations (1)

NYU Langone Health

New York, New York, United States

Key Dates

Start Date

December 24, 2022

Primary Completion Date

August 14, 2023

Completion Date

August 14, 2023

Last Updated

September 19, 2024

Enrollment

ACTUAL participants

Conditions

Primary Progressive Aphasia

Interventions

Transcranial Direct Current Stimulation (tDCS)

DEVICE

Word-Naming Activity

BEHAVIORAL

Speech and Language Interventions for Italian People With PPA

NCT06739967

Primary Progressive Aphasia(PPA)

View study

RECRUITING

UPenn Observational Research Repository on Neurodegenerative Disease

NCT04715399

Frontotemporal Degeneration(FTD)Primary Progressive Aphasia(PPA)+7 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 19, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA)

Inclusion Criteria

Exclusion Criteria

Speech and Language Interventions for Italian People With PPA

UPenn Observational Research Repository on Neurodegenerative Disease

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

Long Term Effect of Brain Stimulation in PPA

Enhancing Language Function in Primary Progressive Aphasia

Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease