A Dose-ranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF])

Inclusion Criteria

• •Subjects with CHF with lower limb edema, pulmonary congestion, or jugular venous distension due to volume overload.
• •Subjects undergoing any of the following diuretic therapies
• •* Loop diuretics at a dosage equivalent to 40 mg/day or more of furosemide tablet/fine granule
• •* Concomitant administration of a loop diuretic and a thiazide diuretic (including similar drugs) at any doses
• •* Concomitant administration of a loop diuretic and a mineralocorticoid receptor antagonist or potassium-sparing diuretic at any doses
• •Subjects who were currently hospitalized or who are able to be hospitalized