Encapsulated Acellular System From Mesenchymal Stem Cells for Dental Pulp Regeneration

Exclusion Criteria

• •Patients not available for the follow-up period (27 weeks).
• •Patients who will undergo orthodontic treatment in the next six months.
• •Patients with reports of allergies to any material or medication used in the study.
• •Pregnant patients.
• •Heavy smokers (more than 10 cigarettes per day).
• •Patients with a history of systemic diseases that impair immune function, such as diabetes mellitus, immunodeficiency, leukemia, Addison's and Cushing's disease.
• •Patients who have used immunosuppressive drugs or chemotherapy, 3 months before the study. Or that they will be irradiated or undergo chemotherapy.
• •Patients who have endodontically treated teeth.
• •Patients who have teeth with signs of severe root resorption.
• •Patients who have teeth with mobility class III or Dens invaginatus.
• •Patients who have teeth with a history of avulsion-type dentoalveolar trauma.
• •Patients who have teeth with clinical and/or radiographic evidence of root fracture.
• •Patients who have teeth that cannot be completely isolated with rubber dam.
• •Patients who have teeth with more than one root or root canal.