SLE fulfilling 2019 ACR/EULAR or 2012 SLICC criteria
willing to perform DXA/ x-Ray investigation (common clinical practice)
willing to donate blood sample
willing to complete questionnaires
the patients should be in a stable disease activity.
You may not be if
Uncontrolled endocrinological disease.
metabolic bone disease other than osteoporosis ( e.g. Paget disease).
celiac disease, inflammatory bowel disease or pancreatic exocrine deficiency resulting in malabsorption
patients lacking medication history information (SLE and bone related medications).
Have any other clinically significant abnormal laboratory value in the opinion of the investigator
Have any intercurrent significant medical illness that the investigator considers would make the candidate unsuitable for the study.
The patients shouldn't be enrolled during a moderate to severe flare of disease requiring an escalation of therapy ( especially glucocorticoid) - no new BILAG A or B in the last 3 months.
Pregnant patients or during the first year after child birth.
