XW014 in Healthy Subjects and Patients With Type 2 Diabetes Mellitus (T2DM)

Exclusion Criteria

• •1. History or clinically significant active disease of the gastrointestinal, cardiovascular, hepatic, neurologic, renal, pancreatic, immunologic, dermatologic, endocrine, genitourinary, or hematologic system
• •2. Uncontrolled hypertension
• •3. History of type 1 diabetes mellitus
• •4. History or current diagnosis of acute or chronic pancreatitis or factors for pancreatitis
• •5. Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 or subjects with suspected medullary thyroid carcinoma
• •6. Existence of any surgical or medical condition that, in the judgment of the Investigator, might interfere with the absorption, distribution, metabolism, or excretion of the investigational product