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Study of the Impact of Mother-of-pearl Nutritional Supplementation on the Prevention of Post-menopausal Osteoporosis: Multicentre, Double-blind Randomized Versus Positive Comparator Study
Post-menopausal osteoporosis and the resulting fractures are an important cause of disability and loss of independence. They also increase the risk of morbidity and mortality. Given potential side effects, hormone replacement therapy is no longer recommended for menopausal women with risk of becoming osteoporotic. The very significant decrease in the use of these treatments is suspected of contributing to a resurgence in the incidence of osteoporotic fractures, particularly in women before the age of 70. There is a need for prevention of osteoporosis.
Mother-of-pearl is a candidate for long-term use due to the combination of its effects: calcium supplementation, anti-resorptive activity and osteoanabolic activity. Our hypothesis is that powdered mother-of-pearl supplementation limits bone loss in postmenopausal women with risk of becoming osteoporotic.
Age
50 - 65 years
Sex
FEMALE
Healthy Volunteers
No
Hôpital Gabriel Montpied
Clermont-Ferrand, France
Clinique Universitaire de Rhumatologie
Grenoble, France
CH Emile Roux
Le Puy-en-Velay, France
Hôpital Edouard Herriot
Lyon, France
APHP - Hôpital Cochin
Paris, France
CH Roanne
Roanne, France
CHU Saint-Etienne
Saint-Etienne, France
Start Date
May 12, 2023
Primary Completion Date
November 1, 2027
Completion Date
November 1, 2028
Last Updated
June 19, 2025
200
ESTIMATED participants
Mother-of-pearl
DIETARY_SUPPLEMENT
Calcium Carbonate
DIETARY_SUPPLEMENT
Lead Sponsor
Centre Hospitalier Universitaire de Saint Etienne
Collaborators
NCT02347865
NCT00377234
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT00303485