Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic Cardiomyopathy

Exclusion Criteria

• •Left ventricular ejection fraction \< 50%
• •LVOT gradient \>30 mmHg at rest or during Valsalva maneuver after discontinuation of BB or CCB respectively
• •History of LVOT gradient \>30 mmHg at rest, during exercise or during Valsalva maneuver.
• •Permanent atrial fibrillation
• •Permanent right ventricular pacing
• •Previous intolerance for Bisoprolol (BB) or Verapamil (CCB)
• •Known present obstructive coronary disease (previous percutaneous coronary intervention is accepted)
• •eGFR \< 40 ml/min
• •Fertile women (\<50 years) who are pregnant (Positive Plasma-HCG), breastfeeding or not using anticonception.
• •Significant liver failure
• •Severe valvular disease
• •Bradycardia (40bpm)
• •Hypotension (systolic \<100mmHg)
• •Other significant comorbidity or risks associated with discontinuation of BB or CCB after individual judgement by the investigators.
• •Unable to understand patient information intellectually or linguistically
• •Unable to perform exercise test.
• •Unable to speak and/or understand Danish.
• •Implantable cardioverter defibrillator (any kind)
• •Pacemaker (any kind)
• •Metal implants like to affect image quality
• •Metal implants that poses a risk during CMR
• •Inability to cope with being in the scanner.