A Study of DS-1211b in Individuals With PseudoXanthoma Elasticum

Exclusion Criteria

• •Have a history of bone fracture in the past 6 months
• •Have a history of active metabolic bone disease, excluding osteopenia or osteoporosis without fragility fracture
• •Have a history of calcium pyrophosphate deposit disease
• •Have a history of hypophosphatasia
• •Have a history of untreated hyperparathyroidism
• •Participated in another interventional research study in the past 60 days.
• •Used bisphosphonate in the preceding 12 months or had plans to use bisphosphonate during the study.
• •Received Vitamin B6 supplementation \>5 mg/day in the month prior to screening and during the study
• •Initiated or changed dose of Vitamin D in the preceding month prior to screening
• •Have an alkaline phosphatase \<lower limit of normal (LLN) range
• •Have a QTcF interval duration \>450 ms at screening
• •Have moderate to severe renal insufficiency
• •Are pregnant or breast-feeding women
• •Are female participants unwilling to use contraceptive methods
• •Have any elective surgery planned during the study period
• •Have any other significant condition (medical, psychiatric, social, or medication) that, in the judgment of the Investigator, would prevent full participation or would be inappropriate for the study