Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Region Skane
With
Lund University, Lund, Sweden
Copenhagen Trial Unit, Center for Clinical Intervention Research
The George Institute for Global Health, Australia
HUS Helsinki University Hospitals, Helsinki, Finland
Medical Research Institute of New Zealand Rangahautia Te Ora, Wellington, New Zealand
University Hospital of Wales
3500 patients who are comatose after cardiac arrest will be included in a trial studying three separate targets. All patients will be randomised to a control or an intervention arm for sedation, temperature and blood pressure targets. These are.
1. Continuous deep sedation for 36 hours or minimal sedation (SEDCARE)
2. Fever management with or without a feedback-controlled device (TEMPCARE)
3. A mean arterial pressure target of \>85mmHg or \>65mmHg. (MAPCARE)
Participants will be followed up at 30 days and 6 months. The primary outcome will be survival at 6 months.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Out-of-hospital cardiac arrest
2. Sustained ROSC - defined as 20 minutes with signs of circulation without the need for chest compressions
3. Unconsciousness defined as not being able to obey verbal commands (FOUR-score motor response of \<4) or being intubated and sedated because of agitation after sustained ROSC.
4. Eligible for intensive care without restrictions or limitations
5. Inclusion within 4 hours of ROSC
You may not be if
1. On ECMO prior to randomization
2. Pregnancy
3. Suspected or confirmed intracranial hemorrhage
4. Previously randomized in the STEPCARE trial
5. Trauma or hemorrhage being the presumed cause of arrest
