Patients will be randomized between SBRT alone (38 Gy in 4 fractions) or SBRT (same schedule) along with short course (6 months) androgen deprivation (STAD). All patients will be treated by intensity modulated radiotherapy. Regarding the combined modality approach, SBRT has to start within 3 months from the first injection of LHRH analogue.
Age
18–90
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Histologically proven prostate adenocarcinoma
IR or HR in the NCCN definition
N0M0 at staging with choline or (preferably) PSMA PET-CT;
ECOG performance status between 0 and 2;
You may not be if
Previous local treatment of the prostate with surgery (radical prostatectomy or cryotherapy)
Previous radiotherapy to the pelvis
Previous chemotherapy for malignancy in past 5 years
Impossibility to implant fiducials for tracking purposes
