Treatment of Non-resectable Bile Duct Cancer with Radiofrequency Ablation or Photodynamic Therapy

Exclusion Criteria

• •1. Tumour not accessible endoscopically
• •2. Known hypersensitivity to porphyrins or to any of the other ingredients of the photosensitizer chosen
• •3. Leukopenia (\< 2000/mm3)
• •4. Thrombocytopenia (\< 100,000 / mm³)
• •5. Severe, uncorrected coagulopathy (at the discretion of the physician)
• •6. Suspected erosion of major blood vessels, because of the risk of life-threatening mass haemorrhage exists
• •7. Porphyria (clinician's assessment) or other light-exacerbated diseases
• •8. Severely impaired liver and or kidney function (at the discretion of the physician)
• •9. Bedridden for more than 50% of the time (similar to ECOG (Eastern Cooperative Oncology Group) grade 3)
• •10. Planned surgical procedure within the next 30 days
• •11. Concurrent eye disease that will require a slit lamp examination within the next 30 days
• •12. Prior radiotherapy within the last four weeks
• •13. Previous PDT or RFA
• •14. Planned liver transplantation
• •15. Fertile women (within two years of their last menstruation) without appropriate contraceptive measures (implanon, injections, oral contraceptives, intrauterine devices, partner with vasectomy) while participating in the trial (participants using a hormone-based method have to be informed of possible effects of the trial medication on contraception)
• •16. Participation in other interventional trials
• •17. Patients under legal supervision or guardianship
• •18. Pregnant or nursing women