Correlation Between Psychological Stress and Progression of Newly Oligodendroglioma Towards Secondary Glioma

Oligodendroglioma belongs to the class of gliomas that represent the most common class of primary malignant human brain tumors in adulthood. After tumor resection, patients still face the possibility of recurrence and even progression to glioblastoma. The immune microenvironment is most likely contributing to their development, but underlying pathomechanisms are only partly understood. The high-level psychological stress can lead to a change in malignant tumors patients' neuroendocrine pathways and correlates with the prognosis outcome. In addition, psychological stress can lead to changes in the immune microenvironment, but if it leads to disease progression in oligodendroglioma towards secondary glioma has not been adequately demonstrated. Grouping process: 60 patients are expected to be enrolled. After enrollment, participants will receive regular tumor in situ fluid (fluid within the surgical cavity, TISF) sampling for tumor mutation burden (TMB) analysis and regular MRI. Under the standard of care, participants will receive psychological stress assessment after being diagnosed. according to five psychological scales, and the patients were grouped according to the cut-off value of each scale, the psychological stress of the patients is measured by distress thermometer (DT), perceived stress scale (PSS), anxiety/depression (HADS), and fear of disease progression scale (PoP-Q-SF). Primary study objectives: * To evaluate the proportion of patients with tumor recurrence * To evaluate the changes in immune markers of acute and chronic psychological stress in patients with oligodendroglioma after diagnosis. * To analyze the classification of recurrent glioma. Secondary study objectives: * To evaluate the progression-free survival of patients with different psychological stress levels. * To evaluate the overall survival of patients with different psychological stress levels. * To evaluate the quality of life of patients with different psychological stress levels. Exploratory objectives: -To evaluate the effect of managing the patient's psychological stress on the patient's immune microenvironment.