Impact of the Presence of Anti-interferon Autoantibodies on the Viral Load in Severe Respiratory Infections

Inclusion Criteria

• •For adult patients :
• •Patients with acute respiratory failure requiring the administration of oxygen\* to maintain peripheral oxygen saturation at at least 90%
• •\* in patients with chronic respiratory failure, an oxygen flow higher than the usual flow or a duration of non-invasive ventilation longer than the usual duration will be required.
• •Patients with influenza, RSV or SARS-CoV-2 infection diagnosed by Reverse Transcription Polymerase Chain Reaction (RT-PCR) or antigen test in the last 7 days
• •Patients hospitalized in participating intensive care units
• •For pediatric patient :
• •In respiratory distress placed on oxygen with signs suggestive of viral infection:
• •1. moderate or absent fever or nasopharyngeal congestion or cough
• •2. signs of acute respiratory distress (polypnea \> 2DS of the normal value, intercostal drawing, thoraco-abdominal sway) with more or less marked hypoxia (SpO2 \< 92% under ambient air),
• •3. and/or significant apnea (associated with bradycardia or desaturation),
• •4. and/or dietary difficulties (reduction of rations to less than 50% of the usual ration).
• •Hospitalized in the pediatric emergency and intensive care unit of Hôpital Femme Mère Enfant (HFME)