Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Astellas Pharma Global Development, Inc.
This is a retrospective database analysis of patients with anemia associated with chronic kidney disease (CKD) treated with ESAs from January 1st 2015 - December 31st 2021. Data will be derived from European Clinical Database (EuCliD).
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
All patients
Patient has a diagnosis of chronic kidney disease valid between January 1st, 2015, and December 31st, 2021 and is documented in the EuCliD database (incident and prevalent patients)
Patient who is treated with renal replacement therapy (RRT) (CKD Stage 5) during the study period
Patient receiving erythropoiesis-stimulating agent (ESA) therapy, within the data collection period having EuCliD data available for a period of the previous 30 days before Index Date but not strictly limited to patients that enter the study period as ESA naïve patients
Patient having provided consent for secondary use of their data for research purposes
Patient has a known ESA administration route (intravenous/subcutaneous)
Patient with a hemoglobin value available at baseline (+/- 20 days allowed) and at least one valid hemoglobin value afterwards
Patient having at least one body weight value available
Hyporesponsive Cohort
Patients meeting the hyporesponsive criteria on at least one occasion. The criteria for ESA hyporesponsive will follow the National Institute for Health and Care Excellence, UK (NICE) guidelines:
* for epoetin alfa, 300 IU/kg/week or more of subcutaneous epoetin or 450 IU/kg/week or more of intravenous epoetin
* for darbepoetin, dose ≥ 1.5 μg/kg per week
Responsive Cohort
Patients with all ESA doses lower than those defined by the hyporesponsive criteria
You may not be if
Patient with evidence of hereditary hemolytic anemia (International Classification of Diseases 10th Revision \[ICD-10\] code D58.9)
Patient receiving transplant within 6 months prior to Index Date
