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Keep this study
Lead
Unity Health Toronto
Magnetic resonance imaging (MRI) scans of MDD-affected brains have revealed changes in structural and functional connectivity compared to healthy subjects. This pilot sub-study examines structural and functional connectivity associated with MDD-affected patient participants' responsiveness to N2O compared to the midazolam placebo, which induces similar sedative effects. The investigators intend to address the changes in brain functional activity and connectivity between baseline and after a four-week intervention course involving weekly nitrous oxide inhalations measured by MRI.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Eligible for main nitrous oxide (SMILE) study
You may not be if
Contraindication for undergoing MRI scans (e.g., hip circumference \< 180 cm or metal in the body)
