First in Human Study of IMGN151 in Recurrent Gynaecological Cancers

Exclusion Criteria

• •1. Participants with ovarian cancer with histologies including clear cell, mucinous, or borderline ovarian tumor.
• •1. With the exception of participants enrolled in Cohort D, participants with ovarian cancer with histologies including endometrioid, sarcomatous histology, mixed tumors containing any of the above histologies, as well as low-grade serous carcinoma.
• •2. For Cohort A, participants with endometrial cancer with histologies other than serous or high-grade Grade 3 endometrioid.
• •3. For Cohort E, participants with cervical cancer with histologies other than adenocarcinoma, squamous cell carcinoma, and adenosquamous carcinoma.
• •2. For Cohort B and Dose Optimization: participants with primary platinum refractory ovarian cancer, defined as disease progression on or within 3 months completion of first platinum-based treatment.
• •3. Radiation therapy of \> 20% of the potential bone marrow
• •4. Participants with \> Grade 1 peripheral neuropathy per Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Note: medication management to achieve Grade 1 (asymptomatic) is acceptable.
• •5. Participants with the following ocular history and/or concurrent disorders:
• •1. Active or chronic corneal epithelial disorders other than non-confluent superficial keratopathy/keratitis, including confluent superficial punctate keratopathy/keratitis (SPK) not expected to resolve to non-confluence or better within the screening window with standard-of-care intervention
• •2. History of corneal transplantation
• •3. Undergoing active postoperative management for refractive surgery, cataract surgery, corneal cross-linking, or corneal complications of surgery
• •4. Active or chronic clinically significant (≥ Grade 3) corneal disorders (for example, Fuch's dystrophy or neurotrophic keratitis)
• •5. Active ocular conditions requiring ongoing treatment/monitoring, such as glaucoma, which is not adequately controlled with medication or surgery, wet age-related macular degeneration requiring intravitreal injections, active diabetic retinopathy with macular edema, presence of papilledema, an ocular condition with high risk of retinal detachment
• •6. Monocular vision with visual acuity in the worse-seeing eye (worse than 20/200 or visual fields less than 20 degrees)
• •6. Serious concurrent illness or clinically relevant active infection.
• •7. A history of multiple sclerosis or other demyelinating disease and/or Lambert-Eaton syndrome (paraneoplastic syndrome)
• •8. Participants with clinically significant cardiac disease.
• •9. A history of hemorrhagic or ischemic stroke (including transient ischemic attack) within 6 months before enrollment
• •10. A history of cirrhotic liver disease (Child-Pugh Class B or C)
• •11. Participants with evidence of pneumonitis on baseline imaging or Participants with a previous clinical diagnosis of noninfectious interstitial lung disease (ILD), including noninfectious pneumonitis
• •12. Participants with prior hypersensitivity to monoclonal antibodies (mAb)
• •13. Females who are pregnant or breastfeeding
• •14. For Dose Optimization and Expansion Phase: Participants who received a prior FRα-targeting agent, with the exception of participants enrolled in the prior FRα-targeting agent, ovarian cancer cohort (Cohort C). Receipt of prior mirvetuximab soravtansine is excluded for all cohorts.
• •15. Untreated or symptomatic central nervous system metastases
• •16. A history of other malignancy within 3 years before enrollment