Study for Adolescents and Adults With Ornithine Transcarbamylase Deficiency to Evaluate Safety and Tolerability of ARCT-810

Inclusion Criteria

• •1. Adequate cognitive ability to understand study requirements and give informed consent
• •2. Males and females aged 12 to 65 years inclusive, at Screening
• •3. Documented diagnosis of OTC deficiency
• •4. Clinical stability (no clinical symptoms of hyperammonemia within 1 month, no hospitalizations for metabolic decompensation within 3 months, ≤ 2 hospitalizations within 1 year)
• •5. Stable protein-restricted diet, dietary supplements, and ammonia scavenger regimen (if applicable) for at least 28 days.
• •6. BMI = 18.0 - 32.0 kg/m2, inclusive for adults, and \>5th percentile for adolescents ≥12 to 17 years
• •7. Must be willing to adhere to contraception guidelines