Transdiagnostic Markers of Cognitive Symptoms in Disorders Affective.

This is a cross-sectional study with the following hypotheses and objectives: 1. Patients will show an objective cognitive deficit with both subjective and objective measures compared to healthy controls. 2. Subjectively and objectively assessed cognitive deficits will show moderate agreement in patients with a depressive episode in partial remission, as each assesses different aspects of cognition. 3. Both the subjective and the objective assessment will have a high agreement between patients with DM and TB, demonstrating the transdiagnostic nature of self-assessed and heteroassessed cognitive deficits. 4. Cognitive Reserve will be a mediating factor in the correlation between subjective and objective cognitive evaluation. 5. BDNF and GSH will be associated with the patients' cognitive deficit and will act as mediators between the subjective and objective assessment. Main Objective: To study the impact of cognitive reserve and trophic factors and oxidative stress as transdiagnostic markers of cognitive symptoms (subjective and objective) in patients with DM and TB. 1. Cognitively assess patients with DM and TB (in a depressive episode) through subjective assessment and objective assessment. 2. Evaluate the possible implementation of objective (SCIP) and subjective (COBRA, PDQ) cognitive assessment instruments. 3. Determine the degree of agreement between both types of cognitive assessment both intra-patient and inter-diagnostic. 4. Determine the factors associated with the degree of agreement between both assessments (Cognitive Reserve, BDNF and GSH) in and between both affective disorders.