Adults receiving first cycle of blinatumomab for relapse/refractory or MRD-positive B-cell Acute Lymphoblastic Leukemia
Adequate renal and hepatic function
Negative for HIV
Negative serum pregnancy test, if applicable
ECOG 0-2
You may not be if
Active CNS involvement by ALL
Relative CNS disorders (seizure, paresis, aphasia, Cerebrovascular ischemia/hemorrhage, severe brain injury, dementia, Parkinson's, cerebellar disease, psychosis, coordination or movement disorder)
Contraindication to receive intrathecal methotrexate
Prior treatment with blinatumomab
Active malignancy other than ALL
Active infection or any other concurrent disease or medical condition that was deemed to interfere with the conduct of the study as judged by the investigator
