Loading clinical trials...

ACTIVE_NOT_RECRUITINGNA

HIIT vs. MICT Training Study

Physiological and Molecular Effects of High-intensity Interval Training (HIIT) vs. Moderate-intensity Continuous Training (MICT)

NCT05513300•Stanford University

View on ClinicalTrials.gov

Summary

The purpose of this study is to compare the impact of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on human health outcomes in healthy sedentary subjects, over 12 weeks of exercise training. The investigators will compare several health parameters, such as changes in multiomics profile, cardiorespiratory fitness, muscle strength, and body composition, before and after 12-week interventions of either HIIT or MICT.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Be 18-65 years of age
•Not be pregnant or lactating in the last 12 months, or planning to become pregnant for the next 4 months. A pregnancy test will be performed on the day of DXA scan in women of child-bearing potential. Not be post-partum during the last 12 months.
•Be generally healthy (a list of medical conditions and/or medication that will exclude participants is listed in the section below)
•Body mass index (BMI) \> 18 to \< 40 kg/m2
•Sedentary in the past year, defined as regular (structured) endurance exercise (e.g., brisk walking, jogging, running, cycling, elliptical, or swimming activity that results in feelings of increased heart rate, rapid breathing, and/or sweating) or resistance training (resulting in muscular fatigue), no more than 1 hour per week.
•Persons bicycling as a mode of transportation to and from work \>1 day/week etc. will not be considered sedentary.
•Leisure walkers are included unless they meet the heart rate, breathing, and sweating criteria noted above.

Exclusion Criteria

•A person may not participate in this study if any of the following applies to them:
•Diabetes (self-report and screening tests), which includes: i) treatment with any hypoglycemic agents (self-report, even for non-diabetic reasons) or ii) fasting glucose \>125 or A1c \>6.4 (screening test).
•Abnormal bleeding or coagulopathy (self-report): history of a bleeding disorder or clotting abnormality.
•Thyroid disease (screening test):
•Thyroid Stimulating Hormone (TSH) value outside of the normal range for the laboratory. Individuals with hypothyroidism may be referred to their primary care provider (PCP) for evaluation and retested; any medication change must be stable for more than 3 months prior to retesting.
•Individuals with hyperthyroidism are excluded, including those with normal TSH on pharmacologic treatment.
•Clinical diagnosis of Chronic Obstructive Pulmonary Disease (COPD) and/or pulmonary hypertension.
•Metabolic bone disease (self-report): i) history of non-traumatic fracture from a standing height or less and/or ii) current pharmacologic treatment for low bone mass or osteoporosis, other than calcium, vitamin D, or estrogen.
•Estrogens, progestins (self-report): supplemental, replacement or therapeutic use of estrogens or progestins within the last 6 months, other than birth control or to control menopausal symptoms.
•Elevated blood pressure readings (screening test): i) age \< 60 years: any history of hypertension; ii) age \> 60 years: resting blood pressure reading higher than 150/90 mmHg.
+24 more criteria

Locations (1)

Stanford University

Stanford, California, United States

Key Dates

Start Date

January 10, 2023

Primary Completion Date

August 11, 2025

Completion Date

August 1, 2026

Last Updated

November 28, 2025

Enrollment

135

ESTIMATED participants

Conditions

LifestyleSedentary

Interventions

Exercise intervention

OTHER

GENESIS Project: Generating Evidence on the Needs of Ecuadorian Adolescents

NCT07485673

Adolescent DevelopmentMental Health Issue+1 more

View study

RECRUITINGNA

High Intensity Interval Training and Insulin Sensitivity in Type 2 Diabetes

NCT06688461

Type 2 DiabetesLifestyle-related Condition+1 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 28, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

HIIT vs. MICT Training Study

Inclusion Criteria

Exclusion Criteria

GENESIS Project: Generating Evidence on the Needs of Ecuadorian Adolescents

High Intensity Interval Training and Insulin Sensitivity in Type 2 Diabetes

WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time

Active Pauses for Musculoskeletal Disorder Prevention in Workers

Nighttime Synchrony of Your Nutrition and Circadian Health

Impact of High-Volume Upper Limb Training on Physical and Cognitive Outcomes