A Phase 1 Study of ONO-2020 in Healthy Participants

Exclusion Criteria

• •1. Mentally or legally incapacitated or has significant emotional problems at the time of the Screening visit or expected during the conduct of the study.
• •2. History or presence of clinically significant medical, surgical or psychiatric condition or disease that in the opinion of the Investigator or Sponsor Medical Monitor might confound the results of the study or pose an additional risk to the participant by their participation in the study.
• •3. hypersensitivity or idiosyncratic reaction to the study interventions, excipients or related compounds, or severe food allergies.
• •4. alcoholism or drug/chemical/substance abuse within the past 2 years prior to the first dosing.
• •5. Use of any drug, including prescription and non-prescription medications, herbal remedies, or vitamin supplements, including St. John's Wort, within 14 days or five half-lives (whichever is longer) of first dosing and throughout the study.
• •6. Use of any drugs known to be significant inducers or inhibitors of cytochrome P450 (CYP) enzymes and/or drug transporter substrates for 28 days prior to the first dosing and throughout the study.
• •7. Participation in another clinical study within 120 days (or five half-lives of the study intervention, whichever is longer) prior to the first dosing.
• •8. Liver function test values are in the abnormal range before inclusion.
• •9. Positive urine drug, alcohol, or cotinine results at Screening or check in.
• •10. Positive results at Screening for active viral infection that include HIV, HBV, HCV, and SARS-CoV-2.
• •11. Seated resting blood pressure is less than 90/40 mmHg or greater than 140/90 mmHg at Screening.
• •12. Seated resting pulse rate is lower than 40 beats per minute (bpm) or higher than 100 bpm at Screening.
• •13. Clinically significant history or presence of ECG findings.
• •14. The participant is a current smoker or has smoked within 3 months of Screening or has a positive urine cotinine at Screening or admission.
• •15. Female who is pregnant or lactating.
• •16. Donation of blood or significant blood loss of 400 mL or more within 90 days prior to the first dosing, or blood donation of 200 mL or more within 30 days prior to the first dosing, or blood plasma or platelet donation within 14 days prior to the first dosing, or blood transfusion within 90 days prior to the first dosing.
• •17. Participants who, in the opinion of the Investigator, are considered unsuitable for any other reason.
• •18. Participants who are vegetarian or vegan or not willing to eat a high-fat breakfast.
• •19. History of significant back pain, significant kyphosis, and or scoliosis or other spinal column deformities.
• •20. History of poor venous access.
• •21. History of hypersensitivity for local anesthetics (Lidocaine).
• •22. History or evidence or fundoscopic findings suggestive of raised intracranial pressure.
• •23. History or evidence of laboratory abnormalities for coagulation parameters or the use of medications that may increase the risk of bleeding.