Evaluation of the Efficacy of SeS2 Shampoo on Subjects Having Dandruff

Inclusion Criteria

• •1. Healthy male or female volunteers;
• •2. Age: 18 to 60 years old included;
• •3. Phototype (Fitzpatrick): I to IV;
• •4. Subjects with hair length \> 2 cm, and preferentially shorter than shoulder length;
• •5. Females of childbearing potential, who are sexually actives, using an effective contraceptive method\* for at least one month before the beginning of the study, and throughout the study;
• •6. Subjects exhibiting moderate to severe dandruff status of scalp at screening
• •7. Subjects having at inclusion visit Day 0:
• •8. total dandruff score (adherent + non-adherent) \> or = 4.5 (ranging from 0 to 10);
• •9. adherent dandruff score \> or = 2.5 (ranging from 0 to 5);
• •10. no limit for non-adherent dandruff score;
• •11. Subjects having on inclusion Day 0, 2 areas with dandruff (score \> 2.5) (one of 1x1cm2, the other of 2 x 2cm2) and 2 areas without dandruff (score \< 1) (one of 1x1cm2, the other of 2 x 2cm2) in the vertex if possible
• •12. Subjects usually using a shampoo 3 times/week and willing to have three times/week shampoos during the course of the study;
• •13. Subjects agreeing to use only the supplied shampoo during all the study;
• •14. Subjects agreeing to have 4 hair areas on the scalp (2 areas of approximately 2 cm x 2 cm and 2 areas approximately 1cmx1cm) for micro flora sample taking (swabs);
• •15. Subjects agreeing to have hair cut around the 4 identified areas (zone of 1x0.5cm cut on the high corner of each area sampling)
• •16. Subjects who demonstrate understanding of the study and willingness to participate as evidenced by voluntary written informed consent and have received a signed and dated copy of the informed consent form.
• •17. Subject affiliated to a social security or insurance system;
• •18. Subjects willing to comply to the study requirements;
• •19. Subjects who are willing not to take part in another clinical study in another investigating centre;
• •20. Subjects who agree to give accurate personal information;
• •21. Subjects who are able to attend all study visits. \* The effective contraceptive methods: sexually active females of childbearing potential should either be surgically sterile (oophorectomy, hysterectomy or tubal ligation), or should use a medically accepted contraceptive regimen: systemic contraceptive (oral, implant, injection), diaphragm or cervical cap with intravaginal spermicide,intravaginal device, intrauterine device (IUD), condom with spermicide
• •1. Healthy male or female volunteers;
• •2. Age: 18 to 60 years old included;
• •3. Phototype (Fitzpatrick): I to IV;
• •4. Subjects with hair length \> 2 cm, and preferentially shorter than shoulder length;
• •5. Females of childbearing potential, who are sexually actives, using an effective contraceptive method\* for at least one month before the beginning of the study, and throughout the study;
• •6. Subjects exhibiting moderate to severe dandruff status of scalp at screening and at D-3;
• •7. Subjects having at inclusion visit Day 0:
• •8. total dandruff score (adherent + non-adherent) \> or = 4.5 (ranging from 0 to 10);
• •9. adherent dandruff score \> or = 2.5 (ranging from 0 to 5);
• •10. no limit for non-adherent dandruff score;
• •11. Subjects having on inclusion Day 0, 2 areas with dandruff (score \> 2.5) (one of 1x1cm2, the other of 2 x 2cm2) and 2 areas without dandruff (score \< 1) (one of 1x1cm2, the other of 2 x 2cm2) in the vertex if possible
• •12. Subjects usually using a shampoo 3 times/week and willing to have three times/week shampoos during the course of the study;
• •13. Subjects agreeing to use only the supplied shampoo during all the study;
• •14. Subjects agreeing to have 4 hair areas on the scalp (2 areas of approximately 2 cm x 2 cm and 2 areas approximately 1cmx1cm) for micro flora sample taking (swabs);
• •15. Subjects agreeing to have hair cut around the 4 identified areas (zone of 1x0.5cm cut on the high corner of each area sampling)
• •16. Subjects who demonstrate understanding of the study and willingness to participate as evidenced by voluntary written informed consent and have received a signed and dated copy of the informed consent form.
• •17. Subject affiliated to a social security or insurance system;
• •18. Subjects willing to comply to the study requirements;
• •19. Subjects who are willing not to take part in another clinical study in another investigating centre;
• •20. Subjects who agree to give accurate personal information;
• •21. Subjects who are able to attend all study visits. \* The effective contraceptive methods: sexually active females of childbearing potential should either be surgically sterile (oophorectomy, hysterectomy or tubal ligation), or should use a medically accepted contraceptive regimen: systemic contraceptive (oral, implant, injection), diaphragm or cervical cap with intravaginal spermicide,intravaginal device, intrauterine device (IUD), condom with spermicide