Lifitegrast 5% for the Treatment of Dry Eye In Habitual Soft Contact Lens Wearers

Inclusion Criteria

• •1. Subjects must read, understand and sign the Statement of Informed Consent
• •2. Subjects must be at least 18 years of age
• •3. Subjects must be habitual soft contact lens (CL) wearers, with a daily, weekly, bi- weekly or monthly replacement schedule
• •4. Habitual contact lenses must have a suitable fit as determined by the investigator
• •5. Subjects must report a history of dry eye symptoms, for which they have used rewetting drops or Artificial Tears (ATs) in the past 30 days
• •6. Subjects must be willing to discontinue the use of Artificial Tears (ATs) and rewetting drops for the duration of the study
• •7. Subjects must have a score of 12 or higher on the CLDEQ (Contact Lens Dry Eye Questionnaire-8) at baseline
• •8. Subjects must have at least 2 of the following signs of dry eye disease:
• •1. High tear osmolarity \> 308 mOsm/L, (milliosmoles per liter) or a difference greater than 8 mOsm/L between eyes
• •2. Any corneal staining
• •3. Any bulbar conjunctival staining
• •4. Low TBUT (tear break up time) (\<10s)
• •5. Schirmer \<10mm in either eye
• •9. Subjects must be able to read at least half of the 20/25 (via entrance Snellen visual acuity) or better in each eye in their current contact lens prescription.
• •10. Subjects currently wearing reusable contact lenses must be willing to use Clear Care solution for cleaning and disinfecting throughout the study.