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Effect of Beta-lactoglobulin Supplementation on the Response of Muscle Protein Synthesis During Limb Immobilisation in Healthy Young Adults
The objectives of this study are to: 1. Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to 5 days of limb immobilisation will attenuate the decrease in integrated free-living rates of MPS during short-term muscle disuse. 2. Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to limb immobilisation will attenuate the decrease in muscle mass and strength during short-term muscle disuse.
The objectives of this study are to: 1. Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to 5 days of limb immobilisation will attenuate the decrease in integrated free-living rates of MPS during short-term muscle disuse. 2. Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to limb immobilisation will attenuate the decrease in muscle mass and strength during short-term muscle disuse. Hypotheses 1. Combining β-lactoglobulin and resistance training for 1 wk prior to 5 d of limb immobilisation will attenuate the decrease in integrated muscle protein synthesis, muscle fibre CSA, quadriceps muscle strength, and leg lean mass during muscle disuse. 2. Combining β-lactoglobulin and resistance training for 1 wk prior to 5 d of limb immobilisation will attenuate the decrease in muscle fibre CSA, quadriceps muscle strength, and leg lean mass during muscle disuse.
Age
18 - 45 years
Sex
ALL
Healthy Volunteers
Yes
King's College London
London, United Kingdom
Start Date
April 1, 2023
Primary Completion Date
March 1, 2024
Completion Date
August 1, 2024
Last Updated
April 26, 2023
24
ESTIMATED participants
Beta-lactoglobulin
DIETARY_SUPPLEMENT
Carbohydrate
DIETARY_SUPPLEMENT
Lead Sponsor
King's College London
Collaborators
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT05216666