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RECRUITINGPhase 2NCT05174611

Vitamin D to Improve Quadricep Muscle Strength

Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size ...

Lead sponsor: Chinese University of Hong Kong•1 locations•View source on ClinicalTrials.gov

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Contacts

Michael Tim-Yun Ong

CONTACT

26364171 michael.ong@cuhk.edu.hk

Sponsors

Lead Sponsor

Chinese University of Hong Kong

Age

18 - 40 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•1. Aged 18-40 with unilateral ACL injury
•2. Sporting injury with a Tegner score of 7
•3. Pre-op serum vitamin D level \<20 ng/ml
•4. 4 months post-ACLR with serum Vitamin D level remained \<20ng/ml
•5. LSI for quadriceps strength \<70% of contralateral leg at 4-month isokinetic assessment
•6. Both knees without history of injury/prior surgery

Exclusion Criteria

•1. Concomitant bone fracture, major meniscus injury or full-thickness chondral injuries requiring altered rehabilitation program post-operatively
•2. Pre-operative radiographic signs of arthritis
•3. Metal implants that would cause interference on MRI
•4. Non-HS graft for ACLR
•5. Patient non-compliant to the rehabilitation program
•6. Regular sunbed users

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 18, 2025Terms

Trial snapshot

StatusRECRUITING

PhasePHASE2

Enrollment60

Start dateMar 2025

Last updatedMar 18, 2025

Condition

Anterior Cruciate Ligament Injuries Quadriceps Muscle Atrophy Anterior Cruciate Ligament Rupture Anterior Cruciate Ligament Tear

Locations shown

The Chinese University of Hong Kong

Hong Kong

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 18, 2025Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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