Single and Multiple Dose Safety, Tolerability, PK and Food Effect Study of HEC73077 in Healthy Subjects

Exclusion Criteria

• •1. Use of \>5 cigarettes per day during the past 3 months.
• •2. Known history of allergy to study drugs，or allergies constitution ( multiple drug and food allergies).
• •3. History of alcoholism or drink regularly within 3 months prior to the study (defined as Alcohol consumption of \> 14 units/week).
• •4. Positive results from urine drug screen test.
• •5. Donation or loss of blood over 450 mL within 3 months prior to screening.
• •6. Subjects suffering from gastrointestinal diseases that can interfere with absorption or metabolism of drugs within 6 months before screening.
• •7. Use of any prescription or non-prescription medications within 14 days prior to initial dosing
• •8. Consume foods or beverages containing caffeine, xanthine, alcohol, and grapefruit within 48 hours prior to initial dosing.
• •9. Subjects who participated in another clinical trial within 3 months prior to initial dosing.
• •10. Female subjects were lactating or had positive serum pregnancy results during the screening or testing period.
• •11. Subjects deemed unsuitable by the investigator for any other reason.