Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement Disorders

Exclusion Criteria

• •1. Individuals with a known alternate neurologic disorder including: idiopathic PD, DLB, PSP, ALS, Alzheimer's, prion disease, frontotemporal dementia, seizure disorder, stroke, or brain tumor
• •2. Individuals with a previous head injury (with 15 minutes or greater loss of consciousness within the past 20 years)
• •3. Individuals with substance abuse, or substance abuse disorder
• •4. Brain MRI indicative of a significant abnormality (i.e. prior hemorrhage or infarct greater than 1 cm3, 3 or more lacunar infarcts, cerebral contusion, encephalomalacia, aneurysm, vascular malformation, subdural hematoma, hydrocephalus, space- occupying lesion).
• •5. Individuals with bipolar disease and schizophrenia
• •6. Concurrent medical conditions that contraindicate study procedures
• •7. Women who are pregnant, nursing, or seeking to become pregnant
• •8. Individuals with claustrophobia
• •9. Non-MRI compatible implanted devices
• •10. Corticosteroid treatment in the past four weeks
• •11. Low affinity binders to TSPO
• •12. Significant cognitive impairment (MoCA score ≤ 23) or poor understanding of study design