A diagnosis of ESKD undergoing maintenance dialysis for at least 12 weeks.
Serum hs-CRP ≥ 2.0 mg/L.
A diagnosis of diabetes mellitus OR ASCVD.
You may not be if
Concomitant use of systemic immunosuppressant drugs.
Part 1 (Phase 2b) excludes subjects with a positive TB or a history of latent TB, whereas Part 2 (Phase 3) excludes active TB but allows inclusion of subjects with a latent TB and at least 4 weeks of prophylactic TB treatment.
Abnormal LFTs.
Any life-threatening disease expected to result in death within 12 months.
A history of GI perforation, inflammatory bowel disease (except fully excised. ulcerative colitis), or peptic ulcer disease.
Clinically significant active infection or history of opportunistic or invasive fungal infection.
